José Luis Marco Contelles
Dr. José Luis Marco Contelles
Profesor de Investigación del CSIC
Laboratorio de Radicales Libres y Química Computacional
Instituto de Química Orgánica General
Consejo Superior de Investigaciones Científicas
C/ Juan de la Cierva, 3
28006-Madrid
e-mail: iqoc21@iqog.csic.es
Licenciado (1979) y Doctor en Medicina por la Universidad Complutense de Madrid (1984). Estancias Post-Doctorales: Dr. Henri-Philippe Husson (Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France (1984-1985). Dr. Wolfgang Oppolzer (Département de Chimie Organique, Université de Genève, Suisse) (1986). Dr. Bert Fraser-Reid (Department of Chemistry, Duke University, Durham, North Carolina, USA) (1988-1989).Premio Extraordinario de Licenciatura (Química Fundamental, Sub-especialidad Química Orgánica) (1979-1980). Premio 2002 Franco-Español de la Sociedad de Química de Francia. Actualmente Profesor de Investigación del CSIC desde 2004.
Líneas de Investigación:
- Síntesis y evaluación biológica de nuevos sistemas heterocíclicos.
- Química organometálica aplicada a la síntesis orgánica (reacción de Pauson-Khand, RCM, carbenos de Ru, PtCl2).
- Desarrollo de nuevos métodos sintéticos en química de radicales libres.
Publicaciones más relevantes
1. SORIANO E, BALLESTEROS P and MARCO-CONTELLES JL. “Theooretical investigation on the mechanisms of the PtCl2-mediated cycloisomerization of polyfunctionalized 1,6-enynes.1.The role of propargylic substituents”.Organometallics 24:3172-3181, 2005.
2. SORIANO E and MARCO-CONTELLES JL. “A DFT-based theoretical investigation on the mechanism of the PtCl2-mediated cycloisomerization of allenynes”. Chemistry : A European Journal 11:521-533, 2005.
3. ANJUM S and MARCO-CONTELLES JL. “PtCl2-Mediated cycloisomerization of unsaturated propargylic carboxylates”. Tetrahedron 61:4793-4803, 2005.
4. SORIANO E, BALLESTEROS P and MARCO-CONTELLES JL. “A theoretical investigation on the mechanism of the PtCl2-mediated cycloisomerization of heteroatom-tethered 1,6-Enynes”. Journal of Organic Chemistry 69: 8018-8023, 2004.
5. CADRAN N, CARIOU K, HERVE G, ABERT C, FENSTERBANK L, MALACRIA M and MARCO-CONTELLES JL. “PtCl2/Catalyzed Cycloisomerization of Allenynes”. Journal of American Chemistry Society, 126:3408-3409, 2004.
6. MARCO-CONTELLES JL, GALLEGO P, RODRÍGUEZ-FERNÁNDEZ M, KHIAR N, DESTABEL C, BERNABÉ M, MARTÍNEZ-GRAU A and CHIARA JL. “Synthesis of aminocyclitols by intramolecular reductive coupling of carbohydrate derived d- and e-functionalized oxime ethers by tributyltin hydride or samarium diiodide derivatives”. Journal of Organic Chemistry 62:7397-7412, 1997.
7. MARCO-CONTELLES JL, DESTABEL C, GALLEGO P, CHIARA JL and BERNABÉ M. “A new synthetic approach to the carbocyclic core of cyclopentane-type glycosidase inhibitors: Synthesis of aminocyclopentitols via free radical cycloisomerization of enantiomerically pure alkyne-tethered oxime ethers derived from carbohydrate derivatives”. Journal of Organic Chemistry 61:1354 –1362, 1994.
8. MARCO-CONTELLES JL, BERNABÉ M, AYALA D and SÁNCHEZ B. “6-endo-dig Free radical carbocyclizations: A new strategy for the synthesis of cyclitols derivatives”. Journal of Organic Chemistry 59:1234 –1235, 1994.
9. MARCO-CONTELLES JL and SANCHEZ B. “Stereoelectronic effects in the 6-exo free radical cyclization of acyclic sugar derivatives: Synthesis of branched chain cyclitols derivatives”. Journal of Organic Chemistry 58:4293-4297, 1993.
10. MARCO-CONTELLES JL, POZUELO C, JIMENO ML, MARTÍNEZ L and MARTÍNEZ-GRAU MA. “6-Exo-free radical cyclization of acyclic carbohydrate intermediates: A new synthetic route to enantiomerically pure polyhydroxylated cyclohexane derivatives”. Journal of Organic Chemistry 57: 2625-2631, 1992.
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