Antonio García García
Dr. Antonio García García
Catedrático de Farmacología
Instituto Teófilo Hernando
Facultad de Medicina
Universidad Autónoma de Madrid
C/Arzobispo Morcillo 4
28029 Madrid. España.
e-mail: agg@uam.es
Licenciado y doctor en Medicina por la Universidad Complutense de Madrid (1970). Director del Instituto Teófilo Hernando. Jefe del Servicio de Farmacología Clínica, Hospital Universitario de la Princesa.
Líneas de Investigación:
--Neurotransmisión.
--Neuroprotección.
Publicaciones más relevantes
1. GARCIA AG, SALA F, REIG JA, VINIEGRA S, FRIAS J, FONTERIZ R and GANDIA L. “Dihydropyridine BAY-K-8644 activates chromaffin cell calcium channels”. Nature 309: 69-71 (1984).
2. MICHELENA P, GARCIA-PEREZ LE, ARTALEJO AR and GARCIA AG. “Separation between cytosolic calcium and secretion in chromaffin cells superfused with calcium ramps”. Proc. Natl. Acad. Sci. USA 90: 3284-3288 (1993).
3. LOPEZ MG, MONTIEL C, HERRERO CJ, GARCIA-PALOMERO E, MAYORGAS I, HERNANDEZ-GUIJO JM, VILLARROYA M, OLIVARES R, GANDIA L, McINTOSH JM, OLIVERA BM and GARCIA AG. “Unmasking the functions of the chromaffin cell ?7 nicotinic receptor by using short pulses of acetylcholine and novel selective blockers”. Proc. Natl. Acad. Sci. USA 95: 14184-14189 (1998).
4. MONTERO M, ALONSO MT, CARNICERO E, CUCHILLO E, ALBILLOS A, GARCIA AG, GARCIA-SANCHO J and ALVAREZ J. “Chromaffin-cell stimulation triggers fast millimolar mitochondrial Ca2+ transients that modulate secretion”. Nature Cell Biol. 2: 57-61 (2000).
5. FUENTEALBA J, OLIVARES R, ALÉS E, TAPIA L, ROJO J, ARROYO G, ALDEA M, CRIADO M, GANDIA L and GARCÍA AG. “A choline-evoked [Ca2+]c signal causes catecholamine release and hyperpolarization of chromaffin cells”. FASEB J. 18: 1468-1470 (2004).
5. MARCO-CONTELLES JL, DO CARMO CARREIRAS M, RODRIGUEZ C, VILLARROYA M and GARCIA AG. “Synthesis and pharmacology of galantamine”. Chem. Rev. 106: 116-332 (2006).
6. GARCIA AG, GARCIA-DE-DIEGO AM, GANDIA L, BORGES R and GARCIA-SANCHO J. “Calcium signalling and exocytosis in chromaffin cells”. Physiol. Rev. 86: 1093-1131 (2006).
7. EGEA J, ROSA AO, SOBRADO M, GANDIA L, LOPEZ MG and GARCIA AG. “Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in a7 nicotinic receptor knockout”. Neuroscience 145: 866-872 (2007).
8. MIRANDA-FERREIRA R, DE PASCUAL R, DE DIEGO AMG, CARICATI-NETO A, GANDIA L, JURKIEWICZ A and GARCIA AG. “Single-vesicle catecholamine release has greater quantal content and faster kinetics in chromaffin cells from hypertensive, as compared to normotensive rats”. J. Pharmacol. Exp. Ther. 324: 685-693 (2008).
9. MIRANDA-FERREIRA R, PASCUAL R, CARICATI-NETO A, GANDIA L, JURKIEWICZ A and GARCIA AG. “Role of the endoplasmic reticulum and mitochondria on quantal catecholamine release from chromaffin cells of control and hypertensive rats”. J. Pharmacol. Exp. Ther. 329: 231-240 (2009).
10. FERNANDEZ-MORALES JC, CORTES-GIL L, GARCÍA AG and DE DIEGO AMG. “Differences in the quantal release of catecholamines in chromaffin cells of rat embryos and their mothers”. Am J Physiol Cell Physiol (in press) (2009).
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