Inicio » Investigación » Investigadores/Researchers » Borges Jurado, Ricardo

Borges Jurado, Ricardo

RICARDO BORGES JURADO, MD, PhD
Full Professor of Pharmacology
Pharmacology Unit, Medical School,
University of La Laguna, Tenerife, Spain
email: rborges@ull.es
                                              Website: http://rborges.webs.ull.es
RESEARCH INTEREST
My research focus on the understanding, at the molecular level, of the regulation of the exocytotic release of catecholamines at the adrenal chromaffin cells. Of particular interest is the exploration of the role of some components of secretory vesicles on such regulation, particularly calcium ions and the proteins chromogranins. Studies of my lab also deal with vascular pharmacology and the development of tools to screen novel compounds with potential therapeutic applications in cardiovascular diseases.
SELECTION OF PUBLICATIONS
1. CARBONE, E.; BORGES, R; EIDEN, L.E.; GARCÍA, A.G. and HERNÁNDEZ-CRUZ, A. (2019), The adrenal chromaffin cells: physiology, pharmacology and disease. Comprehensive Physiology (In press) DOI:10.1002/cphy.c190003
2. MAJDI, S.; LARSSON, A.; NAJAFINOBAR, N.; BORGES, R. and EWING, A.G. (2019), Extracellular ATP regulates the vesicular pore opening in chromaffin cells and increases the fraction released during individual exocytosis events. Anal. Chem. 15, 2459-2466. doi: 10.1021/acschemneuro.8b00722
3. DOMÍNGUEZ, N.; ESTEVEZ-HERRERA, J.; BORGES, R. and MACHADO, J.D. (2014), The interaction between chromogranin A and catecholamines governs exocytosis. FASEB J. 28, 4657-4667.
4. ESTEVEZ-HERRERA, J.; DOMÍNGUEZ, N.; PARDO, M.R.; GONZÁLEZ-SANTANA, A.; WESTHEAD, E.W.; BORGES, R. and MACHADO, J.D. (2016), ATP: The crucial component of secretory vesicles. Proc. Natl. Acad. Sci. USA 113, E4098-4106.
5. ESTÉVEZ-HERRERA, J.; GONZÁLEZ-SANTANA, A.; BAZ-DÁVILA, R.; MACHADO, J.D. and BORGES, R. (2016), The intravesicular cocktail and its role in the regulation of exocytosis. Neurochem. 137, 897-903.
6. DOMÍNGUEZ, N.; ESTEVEZ-HERRERA, J.; BORGES, R. and MACHADO, J.D. (2014), The interaction between chromogranin A and catecholamines governs exocytosis. FASEB J. 28, 4657-4667.
7. PONSATI, B.; CARREÑO, C.; CURTO-REYES, V.; VALENZUELA, B.; DUART, M.J.; VAN DEN NEST, W.; CAULI, O.; BELTRAN, B.; FERNANDEZ, J.; BORSINI, F.; CAPRIOLI, A.; DI SERIO, S.; VERETCHY, M.; BAAMONDE, A.; MENENDEZ, L.; BARROS, F.; DE LA PEÑA, P.; BORGES, R.; FELIPO, V.; PLANELLS-CASES, R. and FERRER-MONTIEL, A. (2012), An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain. Pharmacol Exp. Ther. 341, 634-45.
8. DÍAZ-VERA, J.; CAMACHO, M.; MACHADO, J.D.; DOMÍNGUEZ, N.; MONTESINOS, M.S.; HERNÁNDEZ-FERNAUD, J.R.; LUJÁN, R. and BORGES, R. (2012), Chromogranins A and B are key proteins in amine accumulation but the catecholamine secretory pathway is conserved without them. FASEB J. 26, 430-438.
9. CAMACHO, M.; MACHADO, J.D.; ÁLVAREZ, J and BORGES, R. (2008), Intravesicular calcium release mediates the motion and exocytosis of secretory organelles: A study with adrenal chromaffin cells. Biol. Chem. 283, 22383-22389.
10. GARCÍA, A.G.; GARCÍA DE DIEGO, A.M.; GANDÍA, L.; BORGES, R. and GARCÍA-SANCHO, J. (2006), Calcium signalling and exocytosis in chromaffin cells. Physiol. Rev. 86, 1093-1131
Research ID ORCID
Download CV