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García López, Manuela

GarciaLopez,Manuela

MANUELA G. LÓPEZ, MD, PhD
Professor of Pharmacology
Director of Instituto Teófilo Hernando for Drug Discovery
Universidad Autónoma de Madrid, Madrid
RESEARCH INTEREST
1. Neuropharmacology- mechanism of action of neuroprotective drugs
2. Alzheimer´s disease, stroke and Depression models to evaluate new potentially therapeutic drugs.
3. Neuroinflammation and oxidative stress in the control of neurodegeneration and brain ischemia: implication of Nrf2 and NOXs
4. Impact of a7 nicotinic acetylcholine receptors and melatonin receptors to control neuroinflammation, oxidative stress and neuroprotection.
 SELECTION OF PUBLICATIONS
1. Lorrio, S.,  Gómez-Rangel, V., Negredo, P., Egea, J., Leon, R., Romero, A., Dal-Cim, T., Villarroya, M., Rodriguez-Franco, M.I., Conde, S., Arce, M.P., Roda, J.M., García, A.G. and López, M.G. Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia. Neuropharmacology 67: 403–411. 2013
2. Parada,  E., Egea, J., Buendía, I., Negredo,  P., Cunha, A.C., Cardoso, S., Soares, M.P. and pez, M.G. The microglialα7 acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing HO-1 via Nrf2.  Antioxidants & Redox Signaling.  19(11):1135-48. 2013
3. Martín-de-Saavedra, M.D., Budni, J., Cunha, M.P., Gómez-Rangel, V., Lorrio, S., del Barrio, L., Lastres-Becker, I., Parada, E., Tordera, R.M., Rodrigues, A.L.S., Cuadrado, A. and López, M.G. Nrf2 participates in depressive disorders through an anti-inflammatory mechanism. Psychoneuroendocrinology. doi:pii: S0306-4530(13)00115-7.10.1016/j.psyneuen.2013.03.020
4. Parada, E., Buendía, I., León, R., Negredo, P., Romero, A., Cuadrado, A.,  López, M.G. and Egea, J. Neuroprotective effect of melatonin against ischemia is partially mediated by alfa-7 nicotinic receptor modulation and HO-1 overexpression. J Pineal Res. 56(2):204-12. 2014.
5. López-Iglesias, C. Pérez, J.A. Morales-García, S., Alonso-Gil, A. Pérez-Castillo, D., Caignard, H., Romero, A., López, M.G., Villarroya, M., Conde, S. and Rodríguez-Franco, M.I.. New Neurogenic Melatonin – N,N-Dibenzyl(N-methyl)amine Hybrids as Multifunctional Agents for the Potential Treatment of Alzheimer’s Disease, with Additional Cholinergic, Antioxidant, and Neuroprotective Properties. J. Med. Chem. 57:3773-85. 2014
6. Freitas, A.E., Egea, J., Buendía, I., Gómez-Rangel, V., Parada, E., Navarro, E., Casas, A.I., Wojnicz, A., Avendaño, J., Cuadrado, A.,  Ruiz-Nuño, A., Rodrigues, A.L.S. and M.G. López. Agmatine, by improving neuroplasticity markers and inducing Nrf2, prevents corticosterone-induced depressive-like behavior in mice. Molecular Neurobiology DOI: 10.1007/s12035-015-9182-6
7. Parada, E.,  Buendia, I., Navarro, E., León, R., Avendaño, C., Egea, J. and  López M.G. Microglial HO-1 induction by curcumin provides antioxidant, anti-neuroinflammatory and glioprotective effects.  Molecular Nutrition &Food Research 59:1690-1700. 2015
8. Buendía, I., Parada, E., Navarro, E., León, R., Negredo, P., Egea, J. and  López M.G. Subthreshold concentrations of melatonin and galantamine improves pathological AD hallmarks in hippocampal organotypic cultures. Molecular Neurobiology DOI: 10.1007/s12035-015-9272-5
9. Navarro, E., Buendía, I.,Parada, E., León, R., Jansen-Duerr, P., Pircher, H., Egea J. and López, M.G. Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction. Biochemical Pharmacology 97. 473-481. 2015
10. Kleinschnitz, C., Mencl, S., Kleikers, P.W.M., Schuhmann, M.K., López, M.G., CasasGuijarro, A.I., Reif, A., Schmidt and H.H.H.W. NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage J. Cereb. Blood Flow Metab. (accepted may 2016)
11. Navarro, E., González-Lafuente, L., Pérez-Liébana, I., Buendía, I., López-Bernardo, E., Sánchez-Ramos, C., Prieto, I., Cuadrado, A., Satrustegui, J., Cadenas, S., Monsalve, M. and López, MG. Heme-oxygenase I and PCG-1α regulate mitochondrial biogenesis via microglial activation of alpha7 nicotinic acetylcholine receptors using PNU282987. Antioxid Redox Signal. 2016 Aug 23. [Epub ahead of print] PMID: 27554853

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