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García García, Antonio


Emeritus Professor
Instituto Fundación Teófilo Hernando
Universidad Autónoma de Madrid
1. Neurotransmission and its neurochemical regulation
2. Neuropharmacological and Pharmacological neuroprotection
The studies of the pharmacological and neurochemical regulation of ion channels and calcium signaling have been the focus of my laboratory since 1975. I have projected these studies towards the understanding of the basic principles governing the exocytotic release of catecholamine, neuronal survival, and neuronal death. More recently, my laboratory is making efforts to translate this accumulated knowledge to the understanding of altered neurotransmitter release and cell vulnerability in neurodegenerative processes, particularly Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). Ultimately, the overall effort addresses the search of a neuroprotective medicine capable of delaying AD and/or ALS progression and improve the quality of life of patients suffering these terrible diseases. I recently created the spinoff DNS Neuroscience to ease the transfer of my laboratory knowledge to society.
1. GARCIA, A.G. and KIRPEKAR, S.M.: Release of noradrenaline from slices of cat spleen by pretreatment with calcium, strontium and barium. J. Physiol. 235: 683-713, 1973.
2. GARCIA, A.G., SALA, F., REIG, J.A., VINIEGRA, S., FRIAS, J., FONTERIZ, R. and GANDIA, L.: Dihydropyridine BAY-K-8644 activates chromaffin cell calcium channels. Nature 309: 69-71, 1984.
3. GANDIA, L., GARCIA, A.G. and MORAD, M.: ATP modulation of calcium channels in chromaffin cells. J. Physiol. 470: 55-72, 1993.
4. MONTERO, M., ALONSO, M.T., CARNICERO, E., CUCHILLO, E., ALBILLOS, A., GARCIA, A.G., GARCIA-SANCHO, J. and ALVAREZ, J.: Chromaffin-cell stimulation triggers fast millimolar mitochondrial Ca2+ transients that modulate secretion. Nature Cell Biol. 2: 57-61, 2000.
5. ARIAS, E., ALES, E., GABILAN, N.H., CANO-ABAD, M.F., VILLARROYA, M., GARCIA, A.G. and LOPEZ, M.G.: Galantamine prevents apoptosis induced by b-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors. Neuropharmacology 46: 103-114, 2004.
6. GARCIA, A.G., GARCIA-DE-DIEGO, A.M., GANDIA, L., BORGES, R. and GARCIA-SANCHO, J.: Calcium signalling and exocytosis in adrenal chromaffin cells. Physiol. Rev. 86: 1093-1131, 2006.
7. FERNÁNDEZ-BACHILLER, M.I., PÉREZ, C., GONZÁLEZ-MUÑOZ, G.C., CONDE, S. LÓPEZ, M.G.,  VILLARROYA, M., GARCIA, A.G. and RODRÍGUEZ-FRANCO, I. Novel tacrine–8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer’s disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties. J. Med. Chem. 53: 4927-4937, 2010
8. FERNÁNDEZ-MORALES, J.C., ARRANZ-TAGARRO, J.A., CALVO-GALLARDO, E., MAROTO, M., PADIN, J.F. and GARCIA, A.G. Stabilisers of neuronal and mitochondrial calcium cycling as a strategy for developing a medicine for Alzheimer´s disease. ACS Chem. Neurosci. 3: 873-883, 2012.
9. YAÑEZ, M., MATIAS-GUIU, J., ARRANZ-TAGARRO, J.A., GALAN, L., VIÑA, D., GOMEZ-PINEDO, U., VELA, A., GUERREORO, A., MARTINEZ-VILA, E. and GARCIA, A.G. The neuroprotection exerted by memantine, minocycline and lithium, against neurotoxicity of CSF from patients with amyotrophic lateral sclerosis, is antagonized by riluzole. Neurodeg. Dis. 13: 171-179, 2014.
10. CALVO-GALLARDO, E., DE PASCUAL, R., FERNÁNDEZ-MORALES, J.C., ARRANZ-TAGARRO, J.A., MAROTO, M., NANCLARES, C., GANDIA, L., DE DIEGO, A.M.G., PADÍN, J.F. and GARCÍA, A.G. Depressed excitability and ion currents linked to slow exocytotic fusion pore in chromaffin cells of the SOD1G93A mouse model of amyotrophic lateral sclerosis. Am. J. Physiol. 308: C1-C19, 2015.