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Gandía Juan, Luis

Luis Gandía


Professor of Pharmacology
Instituto Teófilo Hernando for Drug Discovery
Universidad Autónoma de Madrid,
Madrid, Spain
1.Regulation of neuronal communication
2.Fundamental pathways of neurotoxicity and neuronal death
3.Research of neuroprotection targets
4.Animal models of amyotrophic lateral sclerosis
5.Animal models of Alzheimer’s disease
6.Preclinical and clinical development of potential new medicines
1.GARCIA, A.G., SALA, F., REIG, J.A., VINIEGRA, S., FRIAS, J., FONTERIZ, R. and GANDIA, L.: Dihydropyridine BAY‑K‑8644 activates chromaffin cell calcium channels. Nature, 309: 69‑71, 1984.
2.GARCIA, A.G., GARCIA-DE-DIEGO, A.M., GANDIA, L., BORGES, R. and GARCIA-SANCHO, J.: Calcium signalling and exocytosis in chromaffin cells. Physiol. Rev. 86: 1093-1131, 2006.
3.ROSA, J.M., TORREGROSA-HETLAND, C.J., COLMENA, I., GUTIERREZ, L.M., GARCIA, A.G. and GANDIA, L. Calcium entry through slow-inactivating L-type calcium channels preferentially triggers endocytosis rather than exocytosis, in bovine chromaffin cells. Am. J. Physiol 301: C86-C98, 2011.
4.ROSA, J.M., CONDE, M., NANCLARES, C., OROZCO, A., COLMENA, I., DE PASCUAL, R., GARCIA, A.G. and GANDIA, L. Paradoxical facilitation of exocytosis by inhibition of L-type calcium channels of bovine chromaffin cells. Biochem. Biophys. Res. Commun. 410: 307-311, 2011.
5.ROSA, J.M., NANCLARES, C., OROZCO, A., COLMENA, I., DE PASCUAL, R., GARCIA, A.G. and GANDIA, L. Regulation by L-type calcium channels of endocytosis: an overview. J. Mol. Neurosci. 48: 360–367, 2012.
Last three years:
6.LEITE, P.E.C., GANDIA, L., DE PASCUAL, R., NANCLARES, C., COLMENA, I., SANTOS, W.C., LAGROTA-CANDIDO, J. and QUIRICO-SANTOS, T.  Selective activation of a7 nicotinic acetylcholine receptor (nAChRa7) inhibits muscular degeneration in mdx dystrophic mice. Brain Research 1573: 27-36, 2014.
7.HERMAN, P.C. SANCHO, P., CAÑAMERO, M., MARTINELLI, P., MICHI, P., GRESS, T., DE PASCUAL, R., GANDIA, L., GUERRA, C., BARBACID, M., WAGNER, M., VIEIRA, C.R., AICHER, A., REAL, F.X., SAINZ, B. and HEESCHEN, C. Nicotine promotes initiation and progression of K-ras-induced pancreatic cancer via Gata6.dependent dedifferentiation of acinar cells in mice. Gastroenterology 147: 1119-1133, 2014.
8.CALVO-GALLARDO, E., DE PASCUAL, R., FERNÁNDEZ-MORALES, J.C., ARRANZ-TAGARRO, J.A., MAROTO, M., NANCLARES, C., GANDIA, L., DE DIEGO, A.M.G., PADÍN, J.F. and GARCÍA, A.G. Depressed excitability and ion currents linked to slow exocytotic fusion pore in chromaffin cells of the SOD1G93A mouse model of amyotrophic lateral sclerosis. Am. J. Physiol. 308: C1-C19, 2015.
9.CRESPO-CASTRILLO, A., PUNZÓN, E., DE PASCUAL, R., MAROTO, M., PADÍN, J.F., GARCÍA-ALVAREZ, I., NANCLARES, C., RUIZ-PASCUAL, L., GANDÍA, L., FERNÁNDEZ-MAYORALAS, A. and GARCÍA, A.G. Novel synthetic sulfoglycolipid IG20 facilitates exocytosis in chromaffin cells through the regulation of sodium channels. J. Neurochem. 135: 880-896, 2015.
10.CRIADO, M., MULET, J., SALA, F., SALA, S., COLMENA, I., GANDÍA, L., BAUTISTA-AGUILERA, O.M., SAMADI, A., CHIOUA, M. and MARCO-CONTELLES, J. N-benzylpiperidine derivatives as a7 nicotinic receptor antagonists. ACS Chem. Neurosci. 7: 1157-1165, 2016.
11.LAJARÍN-CUESTA, R., NANCLARES, C., ARRANZ-TAGARRO, J.A., GONZÁLEZ-LAFUENTE, L., LOPEZ-ARRIBAS, R., ARAUJO DE BRITO, M., GANDIA, L. and DE LOS RIOS, C. Gramine derivatives targeting Ca2+ channels and Ser/Thr phosphatases: a new dual strategy for the treatment of neurodegenerative diseases. J. Med. Chem. 59: 6265-6280, 2016.
12.DE PASCUAL, R., COLMENA, I., RUIZ-PASCUAL, L., BARAIBAR, A.M., EGEA, J., GANDÍA, L. and GARCÍA, A.G. Regulation by L channels of Ca2+-evoked secretory responses in ouabain-treated chromaffin cells. Pflügers Arch. Eur. J. Physiol. 468: 1779-1792, 2016.
13.LÓPEZ-GIL, A., NANCLARES, C., MÉNDEZ-LÓPEZ, I., MARTÍNEZ-RAMÍREZ, C., DE LOS RIOS, C., PADÍN-NOGUEIRA, J.F., MONTERO, M., GANDÍA, L. and GARCÍA, A.G. The quantal catecholamine release from mouse chromaffin cells challenged with repeated acetylcholine pulses is regulated by the mitochondrial Na+/Ca2+ exchanger. J. Physiol. (in press).