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Egea Máiquez, Javier



Miguel Servet Researcher at IIS Hospital la Princesa
Instituto Fundación Teófilo Hernando
Universidad Autónoma de Madrid,
Madrid, Spain
1. Microglial function in the Healthy Brain
2. Mechanisms involved in the resolution of the inflammation in acute brain injuries (stroke, traumatic brain injury)
1. BENCHEKROUN M, ROMERO A, EGEA J, LEÓN R, MICHALSKA P, BUENDÍA I, JIMENO ML, JUN D, JANOCKOVA J, SEPSOVA V, SOUKUP O, BAUTISTA-AGUILERA OM, REFOUVELET B, OUARI O, MARCO-CONTELLES J, ISMAILI L. The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators. J Med Chem. 2016.
2. PATIÑO P, PARADA E, FARRÉ-ALINS V, MOLZ S, CACABELOS R, MARCO-CONTELLES J, LÓPEZ MG, TASCA CI, RAMOS E, ROMERO A, EGEA J.  Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices. Neurotoxicology 2016 57: 61-68. 2016.
3. BUENDIA I, PARADA E, NAVARRO E, LEÓN R, NEGREDO P, EGEA J*, LÓPEZ MG*. Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures. Mol Neurobiol 53: 3338-3348. 2016.
4. EGEA J*, BUENDIA I, PARADA E, NAVARRO E, LEÓN R, LOPEZ MG. Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection. Biochem Pharmacol 97: 463-72. Review. 2015.
5. PARADA E, BUENDIA I, NAVARRO E, AVENDAÑO C, EGEA J, LÓPEZ MG. Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects. Mol Nutr Food Res 59: 1690-1700. 2015.
6. ROMERO A, RAMOS E, DE LOS RÍOS C, EGEA J, DEL PINO J, REITER RJ. A review of metal-catalyzed molecular damage: protection by melatonin. J Pineal Res 56: 343-370. 2014.
7. ROJO AI, MCBEAN G, CINDRIC M, EGEA J, LÓPEZ MG, RADA P, ZARKOVIC N, CUADRADO A. Redox control of microglial function: molecular mechanisms and functional significance. Antioxid Redox Signal 21: 1766-1801. 2014.
8. PARADA E, BUENDIA I, LEÓN R, NEGREDO P, ROMERO A, CUADRADO A, LÓPEZ MG, EGEA J. Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. J Pineal Res 56: 204-212. 2014.
9. PARADA E, EGEA J, BUENDIA I, NEGREDO P, CUNHA AC, CARDOSO S, SOARES MP, LÓPEZ MG. The microglial α7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2. Antioxid Redox Signal 19: 1135-1148. 2013.
10. EGEA J, MARTÍN-DE-SAAVEDRA MD, PARADA E, ROMERO A, DEL BARRIO L, ROSA AO, GARCÍA AG, LÓPEZ MG. Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation. Neuropharmacology 62: 1082-1090. 2012.

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