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de los Ríos Salgado, Cristóbal

 

DE LOS RIOS, CRISTOBAL

 

CRISTÓBAL DE LOS RÍOS SALGADO, PhD
Associate Researcher of SNS “Miguel Servet”
Instituto de Investigación Sanitaria, H.U. La Princesa.
Instituto Fundación Teófilo Hernando
RESEARCH INTEREST
1. Drug Design and Synthesis
2. Pharmacological neuroprotection
3. Neuropathic Pain

 

SELECTION OF PUBLICATIONS
1. C. LOS RÍOS*, J. EGEA, J. MARCO-CONTELLES*, R. LEÓN, A. SAMADI, I. IRIEPA, I. MORALEDA, E. GÁLVEZ, A.G. GARCÍA, M.G. LÓPEZ, M. VILLARROYA, A. ROMERO. Synthesis, inhibitory activity of cholinesterases and neuroprotective profile of novel 1,8-naphthyridine derivatives. Journal of Medicinal Chemistry 53: 5129-5143. 2010
2.  J. EGEA, C. DE LOS RIOS*. 1,8-Naphthyridine Derivatives as Cholinesterases Inhibitors and Cell Ca2+ Regulators, a Multitarget Strategy for Alzheimer’s Disease. Current Topics in Medicinal Chemistry 11: 2807-2823. 2011
3.  L. GONZALEZ-LAFUENTE, J. EGEA, R. LEÓN, F.J. MARTINEZ-SANZ, L. MONJAS, C. PEREZ, C. MERINO, A.M. GARCIA-DE DIEGO, M.I. RODRIGUEZ-FRANCO, A.G. GARCIA, M. VILLARROYA, M.G. LOPEZ, C. DE LOS RIOS* Benzothiazepine CGP37157 and Its Isosteric 2`-Methyl Analogue Provide Neuroprotection and Block Cell Calcium Entry ACS Chemical Neuroscience 3: 519-529. 2012
4.  C DE LOS RÍOS. Cholinesterase inhibitors: a patent review (2007-2011) Expert Opinion on Therapeutic Patents 22; 853-869. 2012
5.  S. LORRIO, A. ROMERO, L. GONZALEZ-LAFUENTE, R. LAJARÍN-CUESTA, F.J. MARTÍNEZ-SANZ, A. SAMADI, J. MARCO-CONTELLES, A.G. GARCÍA, M. VILLARROYA, M.G. LÓPEZ, C. DE LOS RÍOS* PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice. ACS Chemical Neuroscience 4: 1267-1277. 2013
6.  A. ROMERO, J. EGEA, G.C. GONZÁLEZ-MUÑOZ, M.D. MARTÍN DE SAAVEDRA, L. DEL BARRIO, M.I. RODRÍGUEZ-FRANCO, S. CONDE, M.G. LÓPEZ, M. VILLARROYA*, C. DE LOS RÍOS* ITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer’s Disease. ACS Chemical Neuroscience 5: 770-775. 2014
7. F.J. MARTÍNEZ-SANZ, R. LAJARÍN-CUESTA, A.J. MORENO-ORTEGA, L. GONZÁLEZ-LAFUENTE, J.C. FERNÁNDEZ-MORALES, R. LÓPEZ-ARRIBAS, M.F. CANO-ABAD*, C. DE LOS RÍOS* Benzothiazepìne CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration. ACS Chemical Neuroscience 5: 1626-1636. 2015
8. F.J. MARTÍNEZ-SANZ, R. LAJARÍN-CUESTA, L. GONZÁLEZ-LAFUENTE, A.J. MORENO-ORTEGA, E. PUNZÓN, M.F. CANO-ABAD*, C. DE LOS RÍOS* Neuroprotective Profile of Pyridothiazepines with Blocking Activity of the Mitochondrial Na+/Ca2+ exchanger. European Journal of Medicinal Chemistry 109: 114-123. 2016
9. R. LAJARÍN-CUESTA, R.L. ARRIBAS, C. DE LOS RÍOS* Ligands for Ser/Thr Phosphoprotein Phosphatases: a Patent Review (2005-2015). Expert Opinion on Therapeutic Patents 26: 389-407. 2016
10. R. LAJARÍN-CUESTA, C. NANCLARES, J.A. ARRANZ-TAGARRO, L. GONZÁLEZ-LAFUENTE, R.L. ARRIBAS, M.A. DE BRITO, L. GANDÍA, C. DE LOS RÍOS* Gramine Derivatives Targeting Ca2+ Channels and Ser/Thr Phosphatases: a New Dual Strategy for the Treatment of Neurodegenerative Diseases. Journal of Medicinal Chemistry 59: 6265-6280. 2016

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