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Abad Santos, Francisco

AbadSantos,Francisco

 

FRANCISCO ABAD SANTOS, MD, PhD
Head of section, Clinical pharmacology service
Hospital Universitario de la Princesa
Instituto Fundación Teófilo Herrando, Universidad Autónoma de Madrid
Instituto de Investigación Sanitaria la Princesa (IP)
RESEARCH INTEREST
1. Clinical trials in healthy subjects and patients
2. Evaluation of bioavailability and bioequivalence
3. Pharmacogenetics of metabolizing enzymes, transporters and receptors
SELECTION OF PUBLICATIONS
1. Belmonte, C., Ochoa, D., Román, M., Cabaleiro, T., Talegón, M,, Sánchez-Rojas, S.D., Abad-Santos, F. Evaluation of the relationship between pharmacokinetics and the safety of aripiprazole and its cardiovascular effects in healthy volunteers. J Clin Psychopharmacol. 36(6):608-614. Dec 2016
2. Prieto-Pérez, R., Solano-López, G., Cabaleiro, T., Román, M., Ochoa, D., Talegón, M., Baniandrés, O., López-Estebaranz, J.L., de la Cueva, P., Daudén, E., Abad-Santos, F. New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis. Pharmacogenomics J. Sep 27. 2016 [Epub ahead of print]
3. Moreno, I., Ochoa, D., Román, M., Cabaleiro, T., Abad-Santos, F. Utility of pilot studies for predicting ratios and intrasubject variability in high-variability drugs. Basic Clin Pharmacol Toxicol.  119(2):215-21. Aug 2016
4. Ochoa, D., Prieto-Pérez, R., Román, M., Talegón, M., Rivas, A., Galicia, I., Abad-Santos, F., Cabaleiro, T. Effect of gender and CYP2C9 and CYP2C8 polymorphisms on the pharmacokinetics of ibuprofen enantiomers. Pharmacogenomics. 16(9):939-48. 2015
5. Moreno, I., Ochoa, D., Román, M., Cabaleiro, T., Abad-Santos, F. Effect of truncating AUC at 12, 24 and 48 hr when evaluating the bioequivalence of drugs with a long half-life. Basic Clin Pharmacol Toxicol.  118(1):53-7. Jan 2016
6. Cabaleiro, T., Prieto-Pérez, R., Navarro, R., Solano, G., Román, M., Ochoa, D., Abad-Santos, F., Daudén, E. Paradoxical psoriasiform reactions to anti-TNFα drugs are associated with genetic polymorphisms in patients with psoriasis. Pharmacogenomics J. 16(4):336-40. Aug 2016
7. Wojnicz, A., Gil García, A.I., Román-Martínez, M., Ochoa-Mazarro, D., Abad-Santos, F., Ruiz-Nuño, A. Improvement and validation of a high-performance liquid chromatography in tandem mass spectrometry method for monitoring of omeprazole in plasma. Ther Drug Monit. 37(3):381-8. Jun 2015
8. Román, M., Ochoa, D., Sánchez-Rojas, S.D., Talegón, M., Prieto-Pérez, R., Rivas, Â,, Abad-Santos, F., Cabaleiro, T. Evaluation of the relationship between polymorphisms  in CYP2C19 and the pharmacokinetics of omeprazole, pantoprazole and rabeprazole. Pharmacogenomics. 15(15):1893-901. 2014
9. Cabaleiro, T., Román, M., Gisbert, J.P., Abad-Santos, F. Utility of assessing thiopurine S-methyltransferase polymorphisms before azathioprine therapy. Curr Drug Metab. 13(9):1277-93. Nov 2012
10. Prieto-Pérez, R., Ochoa, D., Cabaleiro, T., Román, M., Sánchez-Rojas, S.D., Talegón, M., Abad-Santos, F. Evaluation of the relationship between polymorphisms in CYP2C8 and CYP2C9 and the pharmacokinetics of celecoxib. J Clin Pharmacol. 53(12):1261-7. Dec 2013

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