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Hernández Guijo, Jesús


Professor of Pharmacology

Instituto Teófilo Hernando

Dept. Farmacología y Terapéutica

Facultad de Medicina

Universidad Autónoma de Madrid, Madrid, Spain



1. Neuronal communication, calcium homeostasis and regulatory mechanisms.
2. Neuronal calcium channels.
3. Synaptic transmission.
4. Neural plasticity.
Electrophysiological studies of ionic currents, action potentials and synaptic transmission in the peripheral nervous system cells (chromaffin cells) and central nervous system (hippocampal neurons). Research interests focus on: 1) the autocrine modulation of voltage-dependent calcium channels by neurotransmitters, and 2) cholinergic receptor pharmacology and their involvement in the modulation of synaptic transmission.
1. Gutiérrez J; Baraibar AM, Albiñana E; Velasco P; Solís, JM and Hernández-Guijo JM “Methylmercury reduces synaptic transmission and neuronal excitability in rat hippocampal slices”. Pflugers Arch. Eur. J. Physiol. (2018) 470: 1221–1230. DOI: 10.1007/s00424-018-2144-x
2. Gameiro I, Michalska P, Tenti G, Cores A, Buendía I, Rojo AI, Georgakopoulos ND, Hernández-Guijo JM, Ramos MT, Wells G, López MG, Cuadrado A, Menéndez JC and Leon R. “Discovery of the first dual GSK3β inhibitor / Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease”. Scientific Reports (2017) 1-15 DOI: 10.1038/srep45701
3. Albiñana E, Luengo JG, Baraibar AM, Muñoz, MD, Gandía L, Solís JM and Hernández-Guijo JM. “Choline induces opposite changes in pyramidal neuron excitability and synaptic transmission through a nicotinic receptor independent process in hippocampal slices”. Pflugers Arch. Eur. J. Physiol. (2017) 469: 779–795 DOI: 10.1007/s00424-017-1939-5
4. Albiñana E, Gutierrez-Luengo J, Hernández-Juarez N, Baraibar AM, Montell E, Vergés J, García AG and Hernández-Guijo JM. “Chondroitin sulfate induces depression of synaptic transmission and modulation of neuronal plasticity in rat hippocampal slices”. Neural plasticity. (2015) 2015:463854. DOI: 10.1155/2015/463854 IF 3,161 (121 de 261, Neuroscience) (JCR 2017)
5. Albiñana E, Segura-Chama P, Baraibar AM, Hernández-Cruz A and Hernández-Guijo JM. “Different contributions of calcium channel subtypes to electrical excitability of chromaffin cells in rat adrenal slices”. J. Neurochem. (2015), 133: 511–521. DOI: 10.1111/jnc.13055
6. González JC, Lignani G, Maroto M, Baldelli P and Hernández-Guijo JM. “Presynaptic muscarinic receptors reduce synaptic depression and facilitate its recovery at hippocampal GABAergic synapses”. Cerb. Cortex. (2014), 24: 1818-1831. DOI: 10.1093/cercor/bht032
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