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Cobos del Moral, Enrique

Associate Professor of Pharmacology
University of Granada, Granada, Spain


Our main interests are to deepen in the knowledge of pain mechanisms and pain pharmacology, and to find and validate new targets for the treatment of chronic pain conditions. We currently focus on:
1. Sigma-1 receptors and paiN
2. Opioid analgesia and side effects
3. Neuro-immune interactions in chronic pain states
4. Behavioral pain outcomes
We are using advanced behavioral approaches combined to histological and molecular biology techniques to dissect the mechanisms of chronic pain. We aim to establish sigma-1 antagonists as promising candidate analgesics and as valid tools for increasing the therapeutic index of opioid drugs. We collaborate with several research groups from academia and industry, testing new drugs with analgesic properties which might worth further development.
1. Montilla-García Á, Tejada MÁ, Ruíz-Cantero MC, Bravo-Caparrós I, Yeste S, Zamanillo D, Cobos EJ, 2019. Modulation by sigma-1 receptor of morphine analgesia and tolerance: nociceptive pain, tactile allodynia and grip strength deficits during joint inflammation. Pharmacol. 10:136. doi: 10.3389/fphar.2019.00136
2. Cobos,E.J., Nickerson,C.A., Gao,F., Chandran,V., Bravo-Caparros,I., Gonzalez-Cano,R., Riva,P., Andrews,N.A., Latremoliere,A., Seehus,C.R., Perazzoli,G., Nieto,F.R., Joller,N., Painter,M.W., Ma,C.H.E., Omura,T., Chesler,E.J., Geschwind,D.H., Coppola,G., Rangachari,M., Woolf,C.J., Costigan,M., 2018. Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling. Cell Rep. 22, 1301-1312.
3. Montilla-Garcia,A., Perazzoli,G., Tejada,M.A., Gonzalez-Cano,R., Sanchez-Fernandez,C., Cobos,E.J., Baeyens,J.M., 2018. Modality-specific peripheral antinociceptive effects of mu-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors. Neuropharmacology 135, 328-342.
4. Montilla-Garcia,A., Tejada,M.A., Perazzoli,G., Entrena,J.M., Portillo-Salido,E., Fernandez-Segura,E., Canizares,F.J., Cobos,E.J., 2017. Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia. Neuropharmacology 125, 231-242.
5. Prezzavento,O., Arena,E., Sanchez-Fernandez,C., Turnaturi,R., Parenti,C., Marrazzo,A., Catalano,R., Amata,E., Pasquinucci,L., Cobos,E.J., 2017. (+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/sigma1 antagonist properties and antinociceptive effects. J.Med.Chem. 125, 603-610.
6. Tejada,M.A., Montilla-Garcia,A., Cronin,S.J., Cikes,D., Sanchez-Fernandez,C., Gonzalez-Cano,R., Ruiz-Cantero,M.C., Penninger,J.M., Vela,J.M., Baeyens,J.M., Cobos,E.J., 2017. Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice. Natl.Acad.Sci.U.S.A 114, 8396-8401.
7. Chiu,I.M., Barrett,L.B., Williams,E.K., Strochlic,D.E., Lee,S., Weyer,A.D., Lou,S., Bryman,G.S., Roberson,D.P., Ghasemlou,N., Piccoli,C., Ahat,E., Wang,V., Cobos,E.J., Stucky,C.L., Ma,Q., Liberles,S.D., Woolf,C.J., 2014. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife 3.
8. Sanchez-Fernandez,C., Montilla-Garcia,A., Gonzalez-Cano,R., Nieto,F.R., Romero,L., Artacho-Cordon,A., Montes,R., Fernandez-Pastor,B., Merlos,M., Baeyens,J.M., Entrena,J.M., Cobos,E.J., 2014. Modulation of peripheral mu-opioid analgesia by sigma1 receptors. Pharmacol.Exp.Ther. 348, 32-45.
9. Sanchez-Fernandez,C., Nieto,F.R., Gonzalez-Cano,R., Artacho-Cordon,A., Romero,L., Montilla-Garcia,A., Zamanillo,D., Baeyens,J.M., Entrena,J.M., Cobos,E.J., 2013. Potentiation of morphine-induced mechanical antinociception by sigma(1) receptor inhibition: role of peripheral sigma(1) receptors. Neuropharmacology 70, 348-358.
10. Cobos,E.J., Ghasemlou,N., Araldi,D., Segal,D., Duong,K., Woolf,C.J., 2012. Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia. Pain 153, 876-884.
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